Licochalcone F alleviates glucose tolerance and chronic inflammation in diet-induced obese mice through Akt and p38 MAPK
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- 作者：Eun-Jung Baka ; Kyung-Chul Choib ; Sungil Jangc ; d ; e ; Gye-Hyeong Woof ; Ho-Geun Yoong ; Younghwa Nah ; Yun-Jung Yood ; e ; Youngseok Leei ; Yangsik Jeongj ; yjeong@yonsei.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Jeong-Heon Chaa ; c ; d ; e ; Jcha@yuhs.ac" class="auth_mail" title="E-mail the corresponding author
- 关键词：Licochalcone F ; Anti-inflammatory effect ; Obesity-induced chronic inflammation ; Diet-induced obese mice
- 刊名：Clinical Nutrition
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：35
- 期：2
- 页码：414-421
- 全文大小：1734 K
文摘
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We synthesized the novel licochalcone F and investigated the biological effects.
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Lico F had anti-inflammatory effects and improved glucose intolerance.
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Lico F attenuated metabolic disorders without body weight gain and fatty liver.
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Lico F provide beneficial effects on obesity-induced chronic inflammation.