Synthesis of licochalcone analogues with increased anti-inflammatory activity

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• 作者：Si-Jun Kim ; Cheol Gi Kim ; So-Ra Yun ; Jin-Kyung Kim ; Jong-Gab Jun
• 关键词：Licohalcone B ; Licohalcone D ; [3 ; 3]-Sigmatropic rearrangement ; anti-Inflammatory effects ; IC50 values of NO production
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：1 January, 2014
• 年：2014
• 卷：24
• 期：1
• 页码：181-185
• 全文大小：818 K

文摘

Licohalcones have been reported to have various biological activities. However, most of licochalcones also showed cytotoxicity even though their versitile utilities. Licochalcones B and D, which have common substituents at aromatic ring B, are targeted to modify the structure at aromatic ring A for inflammatory studies. Licochalcone derivatives (boldFont">1-boldFont">6) thus prepared are compared for their suppression ability of nitric oxide (NO) production and showed 9.94, 4.72, 10.1, 4.85, 2.37 and 4.95 渭M of ICb>50b> values, respectively.