- 作者：Angela A. Rivellese ; Lidia Patti ; David Kaufman ; Jianhui Zhu ; Giovanni Annuzzi ; Olga Vaccaro ; Sven O. Ebbesson ; Wm. James Howard ; Gabriele Riccardi ; Barbara V. Howard
- 关键词：Lipoprotein particle distribution ; Insulin resistance ; Metabolic syndrome ; GOCADAN study ; Alaska Eskimos
- 刊名：Atherosclerosis
- 出版年：2008
- 出版时间：October 2008
- 年：2008
- 卷：200
- 期：2
- 页码：350-358
- 全文大小：531 K
BackgroundMetabolic syndrome (MS) is associated with dyslipidemia, and insulin resistance (IR) may be a main determinant of this dyslipidemia.Objective
To determine how lipoprotein particle concentration and size are related to MS and IR in a population-based sample of Alaska Eskimos.
Design
Participants underwent a physical exam, personal interview, collection of biological specimens, and diagnostic tests.
Setting
This study was conducted in the Norton Sound region of Alaska.
Participants
One thousand one hundred fifty-eight Inupiat Eskimo adults (women = 653, men = 505).
Main outcome measures
Lipoprotein particle profile was evaluated by nuclear magnetic resonance (NMR) and related to presence of MS and level of IR.
Results
Participants with MS had (a) significantly higher concentrations of all VLDLs and a larger VLDL size (women, p = 0.007; men, p = 0.0001); (b) higher concentrations of small LDL (women, p < 0.0001; men, p = 0.09) and lower concentrations of large LDL (women, p < 0.0001), leading to a smaller overall LDL size (women, p < 0.0001; men, p < 0.05); (c) significantly lower concentrations of large HDL (both genders, p < 0.0001) and an increase in intermediate (women, p < 0.05) and small HDL (women, p < 0.0001; men, p < 0.004). Lipoprotein profile with increasing HOMA-IR resembled that of individuals with MS.
Conclusions
In this population MS is characterized by lipoprotein distribution and size abnormalities independent of obesity, age, and other cardiovascular risk factors, including lipid concentration. IR seems the major determinant.