Racial Disparities in Access to and Outcomes of Kidney Transplantation in Children, Adolescents, and Young Adults: Results From the ESPN/ERA-EDTA (European Society of Pediatric Nephrology/European Renal Association−European Dialysis and Transplant Association) Registry

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• 作者：Lidwien A. Tjaden ; MD¹ ; ² ; ^{l.a.tjaden@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author} ; Marlies Noordzij ; PhD¹ ; Karlijn J. van Stralen ; PhD¹ ; Claudia E. Kuehni ; MD³ ; Ann Raes ; MD ; PhD⁴ ; Elisabeth A.M. Cornelissen ; MD ; PhD⁵ ; Catherine O&rsquo ; Brien ; MD ; PhD⁶ ; Fotios Papachristou ; MD ; PhD⁷ ; Franz Schaefer ; MD ; PhD⁸ ; Jaap W. Groothoff ; MD ; PhD² ; Kitty J. Jager ; MD ; PhD¹ ; on behalf of the ESPN/ERA-EDTA Registry Study Group^&lowast ;
• 关键词：Children ; adolescents ; pediatric ; health policy ; renal replacement therapy (RRT) ; kidney transplantation ; renal disease ; racial disparities ; health disparity ; ethnic minority ; immigrant ; Europe
• 刊名：American Journal of Kidney Diseases
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：67
• 期：2
• 页码：293-301
• 全文大小：668 K

文摘

Racial disparities in kidney transplantation in children have been found in the United States, but have not been studied before in Europe.

Study Design

Cohort study.

Setting & Participants

Data were derived from the ESPN/ERA-EDTA Registry, an international pediatric renal registry collecting data from 36 European countries. This analysis included 1,134 young patients (aged ≤19 years) from 8 medium- to high-income countries who initiated renal replacement therapy (RRT) in 2006 to 2012.

Factor

Racial background.

Outcomes & Measurements

Differences between racial groups in access to kidney transplantation, transplant survival, and overall survival on RRT were examined using Cox regression analysis while adjusting for age at RRT initiation, sex, and country of residence.

Results

868 (76.5%) patients were white; 59 (5.2%), black; 116 (10.2%), Asian; and 91 (8.0%), from other racial groups. After a median follow-up of 2.8 (range, 0.1-3.0) years, we found that black (HR, 0.49; 95% CI, 0.34-0.72) and Asian (HR, 0.54; 95% CI, 0.41-0.71) patients were less likely to receive a kidney transplant than white patients. These disparities persisted after adjustment for primary renal disease. Transplant survival rates were similar across racial groups. Asian patients had higher overall mortality risk on RRT compared with white patients (HR, 2.50; 95% CI, 1.14-5.49). Adjustment for primary kidney disease reduced the effect of Asian background, suggesting that part of the association may be explained by differences in the underlying kidney disease between racial groups.

Limitations

No data for socioeconomic status, blood group, and HLA profile.

Conclusions

We believe this is the first study examining racial differences in access to and outcomes of kidney transplantation in a large European population. We found important differences with less favorable outcomes for black and Asian patients. Further research is required to address the barriers to optimal treatment among racial minority groups.