Characterization of tuberculous granulomas in different stages of progression and associated tertiary lymphoid tissue in goats experimentally infected with Mycobacterium avium subsp. hominissuis
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- 作者：Jan Schinkö ; thea ; Jan.Schinkoethe@fli.bund.de" class="auth_mail" title="E-mail the corresponding author ; Heike Kö ; hlerb ; Heike.Koehler@fli.bund.de" class="auth_mail" title="E-mail the corresponding author ; Elisabeth M. Liebler-Tenoriob ; Elisabeth.Liebler-Tenorio@fli.bund.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Granuloma ; Immune response ; Animal model ; Goat ; Non-tuberculous mycobacteria ; Mycobacterium avium subsp. hominissuis ; Tuberculosis ; Lymphoid tissue
- 刊名：Comparative Immunology, Microbiology and Infectious Diseases
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：47
- 期：Complete
- 页码：41-51
- 全文大小：6658 K
文摘
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Oral infection of goats with MAH resulted in granulomas in oGALT and lymph nodes.
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Morphologically distinct granulomas were found in sick and healthy goats.
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Granulomas reflected the heterogeneity of lesions seen in human and ruminant TB.
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Organized granulomas were surrounded by tertiary lymphoid tissue.
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Experimental infection of goats with MAH is a valuable model for TB research.