Signal transduction pathways involved in mechanotransduction in bone cells

详细信息    查看全文

• 作者：Astrid Liedert ; Daniela Kaspar ; Robert Blakytny ; Lutz Claes and Anita Ignatius
• 关键词：Mechanotransduction ; Signal transduction ; Mechanical loading ; Osteoblast ; Osteocyte
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2006
• 出版时间：13 October 2006
• 年：2006
• 卷：349
• 期：1
• 页码：1-5
• 全文大小：217 K

文摘

Several in vivo and in vitro studies with different loading regimens showed that mechanical stimuli have an influence on proliferation and differentiation of bone cells. Prerequisite for this influence is the transduction of mechanical signals into the cell, a phenomenon that is termed mechanotransduction, which is essential for the maintenance of skeletal homeostasis in adults. Mechanoreceptors, such as the integrins, cadherins, and stretch-activated Ca²⁺ channels, together with various signal transduction pathways, are involved in the mechanotransduction process that ultimately regulates gene expression in the nucleus. Mechanotransduction itself is considered to be regulated by hormones, the extracellular matrix of the osteoblastic cells and the mode of the mechanical stimulus.