Equine-Induced Pluripotent Stem Cells Retain Lineage Commitment Toward Myogenic and Chondrogenic Fates
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- 作者：Mattia Quattrocelli1 ; Giorgia Giacomazzi1 ; Sarah Y. Broeckx2 ; Liesbeth Ceelen3 ; Selin Bolca3 ; Jan H. Spaas2 ; 5 ; jan.spaas@anacura.com" class="auth_mail" title="E-mail the corresponding author ; Maurilio Sampaolesi1 ; 4 ; 5 ; maurilio.sampaolesi@med.kuleuven.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：equine stem cells ; myogenic differentiation ; chondrogenic differentiation ; equine iPSCs ; intrinsic lineage propensity
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：12 January 2016
- 年：2016
- 卷：6
- 期：1
- 页码：55-63
- 全文大小：3778 K
文摘
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Equine mesoangioblasts (MABs) are prospectively isolated from syngeneic horses
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Equine iPSCs are obtained from isogenic MABs and MSCs with similar characteristics
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Equine MAB-iPSCs are more prone to the muscle lineage in vivo and in vitro
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Equine MSC-iPSCs display higher propensity for the chondrogenic lineage