Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor
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- 作者：Quynh N. Dinha ; Morag J. Youngb ; Megan A. Evansa ; Grant R. Drummonda ; Christopher G. Sobeya ; 1 ; Sophocles Chrissobolisa ; 1 ; 2 ; s-chrissobolis@onu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：BW ; body weight ; CCL2 ; chemokine (C&ndash ; C motif) ligand 2 ; CCL7 ; chemokine (C&ndash ; C motif) ligand 7 ; CCL8 ; chemokine (C&ndash ; C motif) ligand 8 ; CCL12 ; chemokine (C&ndash ; C motif) ligand 12 ; CCR2 ; chemokine (C&ndash ; C motif) receptor 2 ; DOCA ; deoxycorticosterone acetate ; (IL)-1β ; interleukin-1β ; (IL)-6 ; interleukin-6 ; KW ; kidney weight ; MR ; mineralocorticoid receptor ; PdB ; phorbol-12 ; 13- ; dibutyrate ; SHR-SP ; stroke-prone spontaneously hypertensive rat ; SBP ; systolic blood pressure ; TNF-α ; t
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：1637
- 期：Complete
- 页码：146-153
- 全文大小：2034 K
文摘
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Blood pressure increase by aldosterone was unaffected by endothelial MR deficiency.
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Aldosterone increased cerebrovascular superoxide production capacity.
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Endothelial cell MR-deficiency inhibited aldosterone-induced increase in superoxide.
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Aldosterone increased brain mRNA expression of pro-inflammatory cytokines.
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CCL7 and CCL8-not IL-1β-increases were prevented by endothelial MR deficiency.