Nectandrin B, a nutmeg lignan protects hepatocytes against oxidative damage.
Nectandrin B exerts an indirect antioxidative effect via the activation of Nrf2.
Both ERK and GSK-3β pathways contribute to the activation of Nrf2 and hepatocyte-protection by nectandrin B.
Nectandrin B can inactivate GSK-3β through the activation of AMPK in HepG2 cells.