New function of exonuclease and highly sensitive label-free colorimetric DNA detection
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- 作者：Hongbo Lia ; b ; lihongbo112@163.com" class="auth_mail" title="E-mail the corresponding author ; Suqin Wanga ; Zaisheng Wub ; c ; wuzaisheng@163.com" class="auth_mail" title="E-mail the corresponding author ; Jianguo Xuc ; Guoli Shenb ; Ruqin Yub ; rqyu@hnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Multifunctional probe ; Label-free ; Colorimetric detection ; New function of exonuclease ; p53 gene
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：879-885
- 全文大小：1268 K
文摘
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A colorimetric sensor for p53 gene detection was based on THzyme.
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The novel multifunctional probe was perfectly designed.
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The new exonuclease's function was found that exonuclease III can degrade the G-quadruplex structure.
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This label-free strategy of p53 gene detection is highly sensitive.
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These observations are helpful for the biomedical diagnosis using highly efficient Thzymes.