Distinct functions of PPARγ isoforms in regulating adipocyte plasticity
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- 作者：Dylan Lia ; Feng Zhangc ; Xuan Zhangb ; Chenyi Xueb ; Maria Namwanjea ; Lihong Fana ; d ; Muredach P. Reillyb ; Fang Huc ; Li Qianga ; lq2123@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Obesity ; PPARγ ; Adipocyte ; PPARγ isoforms ; Browning ; Beiging
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 December 2016
- 年：2016
- 卷：481
- 期：1-2
- 页码：132-138
- 全文大小：1591 K
文摘
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PPARγ2, but not PPARγ1, responds to endogenous ligands to induce adipogenesis.
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PPARγ isoforms regulate distinct sets of white and brown adipocyte genes.
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PPARγ isoforms have opposite correlations with adiposity in humans.