Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status
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- 作者：Camilla A. Richmond1 ; 3 ; Manasvi S. Shah2 ; 3 ; Luke T. Deary2 ; Danny C. Trotier2 ; Horatio Thomas2 ; 3 ; Dana M. Ambruzs2 ; Lijie Jiang2 ; Bristol B. Whiles4 ; Hannah D. Rickner2 ; Robert K. Montgomery1 ; 3 ; Alessio Tovaglieri2 ; Diana L. Carlone2 ; 3 ; 4 ; David T. Breault2 ; 3 ; 4 ; david.breault@childrens.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：dormant ; quiescent ; intestinal stem cells ; PTEN ; fasting ; MTORC1
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：22 December 2015
- 年：2015
- 卷：13
- 期：11
- 页码：2403-2411
- 全文大小：2751 K
文摘
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Dormant stem cells (d-ISCs) contribute to intestinal regeneration after fasting
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Decreased nutrients lead to transient PTEN inhibition and increased d-ISC numbers
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Cell-autonomous activation of PI3K→AKT→mTORC1 signaling mediates d-ISC response
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PTEN is essential for d-ISC maintenance and intestinal regeneration