The TULIP superfamily of eukaryotic lipid-binding proteins as a mediator of lipid sensing and transport
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- 作者：Vikram Alva ; vikram.alva@tuebingen.mpg.de" class="auth_mail" title="E-mail the corresponding author ; Andrei N. Lupas
- 关键词：TULIP domain ; SMP-like ; BPI-like ; Takeout-like ; ERMES ; Lipid exchange
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1861
- 期：8
- 页码：913-923
- 全文大小：1876 K
文摘
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TULIP proteins are important for lipid sensing and transport in eukaryotes.
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TULIP proteins bind hydrophobic ligands in their central cavity.
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Many members of the TULIP superfamily were already established at the time of the Last Eukaryotic Common Ancestor.
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The SMP domain is emerging as a mediator of phospholipid exchange at membrane contact sites.