Increased expression of HERPUD1 involves in neuronal apoptosis after intracerebral hemorrhage

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• 作者：Wensen Ding^a ; ^b ; ¹ ; Rongrong Chen^b ; ¹ ; Chunshuai Wu^b ; Weihai Chen^b ; Hongtian Zhang^b ; Xingjuan Fan^a ; Hongmei Wang^a ; ^b ; Yuteng Ji^a ; ^b ; Lili Xie^a ; ^b ; Xiaojin Ning^a ; ^b ; Lihua Shen^a ; ^{ntfyslh@yeah.net}
• 关键词：Intracerebral hemorrhage ; HERPUD1 ; Neuron ; Apoptosis
• 刊名：Brain Research Bulletin
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：128
• 期：Complete
• 页码：40-47
• 全文大小：2295 K
• 卷排序：128

文摘

Expression of HERPUD1 was obviously increased around the hematoma in rat ICH model. The expression of apoptosis markers including cytochrome c (cyt c) and active caspase-3 increased accompanied to HERPUD1 in vivo. HERPUD1 silence brought about up-regulation of cyt c and active caspase-3 coupled with increased cell apoptosis in vitro model. HERPUD1 might play a protective role in ICH-induced neuronal apoptosis in rat models. ER stress might play a part in the complicated and various mechanism of ICH.