Glycyrrhizin attenuates isoflurane-induced cognitive deficits in neonatal rats via its anti-inflammatory activity
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- 作者：W. Wang ; X. Chen ; J. Zhang ; Y. Zhao ; S. Li ; L. Tan ; J. Gao ; X. Fang ; A. Luo ; alluo@tjh.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer&rsquo ; s disease ; EDTA ; ethylenediaminetetraacetic acid ; ELISA ; enzyme-linked immunosorbent assay ; HMGB1 ; high-mobility group box 1 ; LPS ; lipopolysaccharide ; MWM ; Morris Water Maze
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：316
- 期：Complete
- 页码：328-336
- 全文大小：1304 K
文摘
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Glycyrrhizin attenuates isoflurane-induced cognitive deficits in neonatal rats.
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Glycyrrhizin alleviates isoflurane-induced hippocampal neuroinflammation.
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Isoflurane-induced neuroinflammation is related to the activation of HMGB1/NFκB.
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Glycyrrhizin mitigates isoflurane-induced hippocampal apoptosis in neonatal rats.
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Glycyrrhizin restores synaptic protein synthesis in neonatal rats.