A sensitive non-derivatization method for apramycin and impurities analysis using hydrophilic interaction liquid chromatography and charged aerosol detection
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- 作者：Zhen Longa ; Zhimou Guob ; guozhimou@dicp.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Xiaoda Liua ; Qi Zhangc ; Xingguo Liua ; Yan Jina ; yan.jin@thermofisher.com" class="auth_mail" title="E-mail the corresponding author ; Lina Lianga ; Huisu Lid ; Jie Weib ; Ningpeng Wud
- 关键词：Hydrophilic interaction liquid chromatography ; Impurity ; Apramycin ; Charged aerosol detector
- 刊名：Talanta
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：423-429
- 全文大小：630 K
文摘
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A non-derivatization method was optimized for apramycin and related compounds.
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More than 16 impurities were separated from apramycin.
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The current method was compared with BP2010 recommended method.
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Impurities of apramycin were analyzed by MS.
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Chromatographic mode, mobile phase and pretreatment were systematically investigated.