LincRNA-ROR promotes invasion, metastasis and tumor growth in pancreatic cancer through activating ZEB1 pathway
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- 作者：Han-xiang Zhana ; Yao Wangb ; c ; Ce Lib ; c ; Jian-wei Xua ; Bin Zhoud ; Jian-kang Zhua ; Hai-feng Hana ; Lei Wanga ; Yun-shan Wangb ; wangyunshan135@126.com" class="auth_mail" title="E-mail the corresponding author ; San-yuan Hua ; husanyuan1962@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pancreatic cancer ; LincRNA-ROR ; Epithelial-mesenchymal transition ; ZEB1 ; Metastasis
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：374
- 期：2
- 页码：261-271
- 全文大小：5084 K
文摘
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LincRNA-ROR is upregulated in pancreatic cancer (PC) tissues.
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LincRNA-ROR promotes PC cells proliferation and invasion in vitro, enhanced tumorigenic and metastatic capacities in vivo.
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LincRNA-ROR enhances ZEB1 expression in PC.
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LincRNA-ROR mediates EMT, migration, and metastasis in PC may partly by activation of ZEB1 through inhibition of p53.