Synthesis and evaluation of the cytotoxic activity of novel ethyl 4-[4-(4-substitutedpiperidin-1-yl)]benzyl-phenylpyrrolo[1,2-a]quinoxaline-carboxylate derivatives in myeloid and lymphoid leukemia cell lines
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- 作者：Vanessa Desplata ; b ; 1 ; Marian Vincenzic ; d ; e ; 1 ; Romain Lucasc ; d ; Sté ; phane Moreauc ; d ; Solè ; ne Savrimoutouc ; d ; Noë ; l Pinaudf ; Jordi Lesbordesc ; d ; Elodie Peyrillesc ; d ; Mathieu Marchivieg ; Sylvain Routierh ; Pascal Sonneti ; Filomena Rossie ; Luisa Rongac ; d ; Jean Guillonc ; d ; jean.guillon@u-bordeaux.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pyrrolo[1 ; 2-a]quinoxaline ; Synthesis ; Cytotoxic activity ; Cancer ; Leukemia
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：4 May 2016
- 年：2016
- 卷：113
- 期：Complete
- 页码：214-227
- 全文大小：1005 K
文摘
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Synthesis of novel ethyl pyrrolo[1,2-a]quinoxaline-carboxylate derivatives.
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Their cytotoxicities were evaluated against five different leukemia cell lines.
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Most compounds showed cytotoxic potential against all leukemia cell lines tested.
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New compounds with IC50 in the micromolar range were identified.