Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage
详细信息 查看全文
- 作者：Sven Malchow1 ; Daniel S. Leventhal1 ; Victoria Lee1 ; Saki Nishi1 ; Nicholas D. Socci2 ; Peter A. Savage1 ; psavage@bsd.uchicago.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：17 May 2016
- 年：2016
- 卷：44
- 期：5
- 页码：1102-1113
- 全文大小：2833 K
文摘
- •
Aire impacts the peripheral repertoire of both Treg cells and Tconv cells
- •
The autoimmune defect in Aire−/− mice maps to the Tconv cell compartment
- •
Treg-biased clones are diverted into the Tconv cell subset in Aire−/− mice
- •
Diverted clones dominate the Tconv cell infiltrate in prostatic lesions