Role of mitochondria in apoptotic and necroptotic cell death in the developing brain
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- 作者：Claire Thorntona ; Henrik Hagberga ; b ;
- 关键词：AMPA ; 伪-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ; Apaf-1 ; apoptotic protease activating factor 1 ; CAD ; caspase-activation DNase ; cyt c ; cytochrome c ; Cy ; cyclophilin ; Drp-1 ; dynamin-related protein 1 ; ENDO ; endonuclease ; AIF ; apoptosis-inducing factor ; ATP ; adenosine triphosphate ; MOMP ; mitochondrial outer membrane permeabilization ; MP ; mitochondrial permeabilization ; NMDA ; N-methyl-D-aspartate ; HI ; hypoxia&ndash ; ischemia ; LPS ; lipopolysaccharide ; MLKL ; mixed lineage kinase domain-like
- 刊名：Clinica Chimica Acta
- 出版年：2015
- 出版时间：7 December 2015
- 年：2015
- 卷：451
- 期：part_PA
- 页码：35-38
- 全文大小：532 K
文摘
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Hypoxic-ischemic encephalopathy induces secondary brain injury characterized by delayed energy failure and excitotoxicity.
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Hypoxia-ischemia triggers accumulation of reactive oxygen species andintracellular calcium, which induces mitochondrial dysfunction.
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Mitochondrial impairment can cause Bax-dependent mitochondrial permeabilization, which triggers release of pro-apoptotic proteins and cell death.
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During the recovery phase, Inflammation is produced leading to death receptor activation and induction of necroptosis.