MLKL inhibition attenuates hypoxia-ischemia induced neuronal damage in developing brain
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- 作者：Yi Qua ; b ; 1 ; quyi712002@163.com" class="auth_mail" title="E-mail the corresponding author ; Jing Shia ; b ; 1 ; Ying Tanga ; b ; Fengyan Zhaoa ; b ; Shiping Lia ; b ; Junjie Menga ; b ; Jun Tanga ; b ; Xuemei Linb ; Xiaodong Pengc ; Dezhi Mua ; b ; d ; dezhi.mu@ucsf.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; BHA ; butylated hydroxyanisole ; CCA ; common carotid artery ; Drp1 ; dynamin-related protein-1 ; HI ; hypoxia-ischemia ; MLKL ; mixed lineage kinase domain-like protein ; NAC ; N-acetylcysteine ; Nec-1 ; necrostatin 1 ; NSS ; neurological severity score ; OGD ; oxygen-glucose deprivation ; PGAM5 ; phosphoglycerate mutase family member 5 ; RIP1 ; receptor interacting protein kinase 1 ; RIP3 ; receptor interacting protein kinase 3 ; ROS ; reactive oxygen species ; SD ; Sprague&ndash ; Dawley ; TRP
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：279
- 期：Complete
- 页码：223-231
- 全文大小：1110 K
文摘
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The interaction of RIP1-RIP3 with MLKL increased in OGD/zVAD treated neurons.
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MLKL inhibition diminished RIP1-RIP3-MLKL interaction and attenuated neuronal death.
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Translocation of oligomerized MLKL to neuronal membrane resulted in cell necroptosis.
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MLKL inhibition attenuated brain damage induced by hypoxia-ischemia in neonatal rats.