A silent allele in the locus D5S818 contained within the PowerPlex®21 PCR Amplification Kit
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- 作者：Ling Chena ; 1 ; Yunchun Taia ; Pingming Qiua ; Weian Dua ; Chao Liua ; b ; liuchaogzf@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Forensic science ; Short tandem repeat ; Paternity test ; Silent allele ; Single locus mismatch ; D5S818
- 刊名：Legal Medicine
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：17
- 期：6
- 页码：509-511
- 全文大小：779 K
文摘
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Three paternity tests cases were found with a single locus mismatch at the locus D5S818 with PowerPlex®21 PCR Amplification Kit (Promega).
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The single locus mismatch is due to the existence of a silent allele 12 in all the three families.
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The silent allele 12 is due to a point mutation that changed cytosine to adenine at 90 nucleotides upstream from the 5′ end of the AGAT repeat sequences.