Highly diastereoselective synthesis of tertiary alcohols via intramolecular Baylis-Hillman reaction using less reactive acrylamides as activated alkenes and ketones as electrophiles
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- 作者：Deevi Basavaiah ; basavaiahdchem@uohyd.ac.in ; Guddeti Chandrashekar Reddy ; Balthu Lingaiah ; Ram Tilak Naganaboina
- 关键词：Diastereoselective synthesis ; Intramolecular Baylis-Hillman reaction ; α-Methylene-γ-lactam framework ; Tertiary alcohols
- 刊名：Tetrahedron
- 出版年：2017
- 出版时间：16 February 2017
- 年：2017
- 卷：73
- 期：7
- 页码：859-867
- 全文大小：839 K
- 卷排序：73
文摘
A simple and convenient protocol for highly diastereoselective intramolecular Baylis-Hillman (IBH) reaction of substrates containing less reactive acrylamides as activated alkene and ketones with α-chiral center (racemic) as electrophile components, thus producing α-methylene-γ-lactam frameworks having β-tertiary alcoholic functional group, has been developed.