Design, synthesis and docking studies of novel 1,2-dihydro-4-hydroxy-2-oxoquinoline-3-carboxamide derivatives as a potential anti-proliferative agents

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• 作者：Saleha Banu^a ; Rajitha Bollu^a ; Rajashaker Bantu^a ; Lingaiah Nagarapu^a ; ; Sowjanya Polepalli^b ; Nishant Jain^b ; Radhika Vangala^c ; Vijjulatha Manga^c
• 关键词：Roquinimex ; 1 ; 2-dihydro-4-hydroxy-2-oxoquinoline-3-carboxamides ; Piperazines ; Anti-proliferative ; Multiple sclerosis ; Cell lines and molecular modeling
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：400-410
• 全文大小：1028 K
• 卷排序：125

文摘

A series of novel 1,2-dihydroquinoline-3-carboxamide derivatives were efficiently synthesized. Propanoic acid linker has influenced the potency of anti-proliferative activity. Compounds 8d and 8e exhibited promising anti-proliferative activity. Compounds 8d and 8e showed good docking with tubulin protein. First report on the synthesis and in vitro anti-proliferative evaluation.