Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent
详细信息 查看全文
- 作者：Feng Cheng1 ; Lingling Wang1 ; Yunfeng Shen ; Jun Xia ; Heng Chen ; Yuanqiang Jiang ; jiangyuanqiangwuxi@163.com" class="auth_mail" title="E-mail the corresponding author ; Mize Lu ; lumizewuxi9@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acute myeloid leukemia ; mTOR ; WYE-687 ; Apoptosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：5 February 2016
- 年：2016
- 卷：470
- 期：2
- 页码：324-330
- 全文大小：1041 K
文摘
- •
WYE-687 inhibits survival and proliferation of human AML cells/progenitor cells.
- •
WYE-687 induces apoptotic death of human AML cells/progenitor cells.
- •
WYE-687 inhibits mTORC1/2 activation in human AML cells/progenitor cells.
- •
WYE-687 inhibits U937 xenograft growth in SCID mice.