Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice
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- 作者：Xuemei Baia ; Song Liua ; Lin Yuana ; Yunkai Xiea ; Tong Lia ; Lingxiao Wanga ; Xueer Wanga ; Tiantian Zhanga ; Shucun Qinc ; Guohau Songc ; Li Geb ; juliagl@126.com" class="auth_mail" title="E-mail the corresponding author ; Zhen Wanga ; wangzhen@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chop ; C/EBP homologous protein ; CNS ; central nervous system ; ER ; endoplasmatic reticulum ; ERK ; extracellular signal-regulated kinase ; GRP78 ; glucose-regulated protein 78 ; HI ; hypoxia&ndash ; ischemia ; HIBD ; hypoxic-ischemic brain damage ; HS ; hydrogen-rich saline ; MAPK ; mitogen-activated protein kinase ; PBS ; phosphate buffered saline ; PFA ; paraformaldehyde ; RT-PCR ; reverse transcription&ndash ; polymerase chain reaction ; UPR ; unfolded protein response
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：1646
- 期：Complete
- 页码：410-417
- 全文大小：4126 K
文摘
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Hydrogen-rich saline exerts neuroprotection against HIBD in neonatal mouse.
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Hydrogen-rich saline reduced ER stress after HI.
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Hydrogen-rich saline induced autophagy after HI.