Trends, characteristics, and incidence of anaphylaxis in 2001-2010: A population-based study

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• 作者：Sangil Lee ; MD ; MS^a ; ^{lee.sangil@mayo.edu} ; Erik P. Hess ; MD ; MSc^b ; Christine Lohse ; MS^b ; Waqas Gilani ; MD^b ; Alanna M. Chamberlain ; PhD^c ; Ronna L. Campbell ; MD ; PhD^b
• 关键词：Anaphylaxis ; food allergy ; venom allergy ; medication allergy ; epidemiology ; incidence rate
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：139
• 期：1
• 页码：182-188.e2
• 全文大小：1047 K
• 卷排序：139

文摘

Anaphylaxis is a potentially life-threatening systemic allergic reaction.ObjectiveWe aimed to determine the incidence rate and causes of anaphylaxis during a 10-year period in Olmsted County, Minnesota.MethodsUsing the resources of the Rochester Epidemiology Project, a comprehensive records linkage system, we performed a population-based incidence study in Olmsted County, Minnesota, from 2001 through 2010. All cases with a diagnosis of anaphylactic shock and 20% of cases with related diagnoses were manually reviewed. The relationships of age group, sex, and year of anaphylaxis with incidence rates were assessed by fitting Poisson regression models.ResultsSix hundred thirty-one cases of anaphylaxis were identified. The median age was 31 years (interquartile range, 19-44 years). The overall age- and sex-adjusted incidence rate was 42 (95% CI, 38.7-45.3) per 100,000 person-years. There was a significant increase in the overall incidence of anaphylaxis during the study period, with an average increase of 4.3% per year (P < .001). In addition, there was a 9.8% increase per year in the incidence rate of food-related anaphylaxis. Food-related anaphylaxis was most common in children aged 0 to 9 years, venom-related anaphylaxis was most common in those 20 to 39 years of age, and medication-related anaphylaxis was most common in those 30 to 39 years of age.ConclusionThe overall incidence rate of anaphylaxis was 42 per 100,000 person-years from 2001-2010 in Olmsted County, Minnesota. The incidence of anaphylaxis increased over time, and several inciting triggers were uniquely associated with different age groups.