文摘
This study shows direct binding between MRP1 Linker 1 (L1MRP1) domain and α- and β-tubulin subunits, using a scanning peptide approach. Four short and dispersed sequences in L1MRP1 domain interact with α/β-tubulin subunits. Each sequence in L1MRP1-tubulin binding domain contains predicted protein kinase C/A site. Substituting 3 of 4 serine with aspartic acid, but not alanine, in L1MRP1 binding domains inhibit their binding to tubulin subunits.