Synergistic role of β-catenin1 and 2 in ovarian differentiation and maintenance of female pathway in Nile tilapia
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- 作者：Limin Wua ; 1 ; Fengrui Wua ; b ; 1 ; Lang Xiea ; Deshou Wanga ; wdeshou@swu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Linyan Zhoua ; yanlinzhou916@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：β-cat1 and β-cat2 ; Expression ; Interaction ; TALENs ; Ovarian differentiation
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：427
- 期：Complete
- 页码：33-44
- 全文大小：4989 K
文摘
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Two β-cats were identified from Nile tilapia, their cellular localization was confirmed in teleosts ovary.
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Fish β-cat1 activates the TOPFlash reporter, whereas β-cat2 does not.
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Inhibition of the canonical Wnt/β-cat signal pathway cause the female gonad masculinization.
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Two β-cats probably play synergistic roles in ovarian differentiation and repression male pathway gene expression in tilapia.