Inpatient Statin Use Is Associated with Decreased Mortality of Acute Stroke Patients with Very Low Low-Density Lipoprotein Cholesterol

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• 作者：Bo Song ; MD ; PhD^&lowast ; ; Yilong Wang ; MD ; PhD^&dagger ; ; Xingquan Zhao ; MD ; PhD^&dagger ; ; Liping Liu ; MD ; PhD^&dagger ; ; Chunxue Wang ; MD ; PhD^&dagger ; ; Anxin Wang ; MD^&dagger ; ; Wanliang Du ; MD ; PhD^&dagger ; ; Yongjun Wang ; MD^&dagger ; ; ^&lowast ; ; ^{yongjunwang1962@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Yuming Xu ; MD ; PhD^&lowast ; ; ^{xuyuming@zzu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Statin ; ischemic stroke ; very low LDL-C ; prognosis
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：24
• 期：10
• 页码：2369-2374
• 全文大小：333 K

文摘

To investigate the potential benefits of inpatient statin therapy on mortality of acute stroke patients with very low admission low-density lipoprotein cholesterol (LDL-C) level (<1.81 mmol/L).

Methods

The acute stroke patients with admission LDL-C level less than 1.81 mmol/L were enrolled from the China National Stroke Registry. The patients were divided into statin group and non–statin group during hospitalization. The association between statin therapy and mortality of participants in 1 year was analyzed by multivariable binary logistic regression models.

Results

A total of 1018 patients were enrolled, and the cumulative mortality rate was 10.1% at 3 months, 13.1% at 6 months, and 15.9 % at 1 year. The all-cause mortality rate in statin group was significantly lower than that in non–statin group (3.6% versus 13.7% at 3 months, P < .001; 6.2% versus 16.9% at 6 months, P < .001; 8.4% versus 20% at 1 year, P < .001). The logistic analyses showed that statin therapy during hospitalization was independently associated with decreased mortality at 3 months (odds ratio [OR], .35; 95% confidence interval [CI], .18-.67), at 6 months (OR, .42; 95% CI, .25-.73) and at 1 year (OR, .47; 95% CI, .29-.76).

Conclusions

Statin use during hospitalization could decrease mortality of acute ischemic stroke patients with very low admission LDL-C.