Effects of triazole fungicides on androgenic disruption and CYP3A4 enzyme activity

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• 作者：Xuan Lv^a ; ^b ; Liumeng Pan^a ; Jiaying Wang^a ; Liping Lu^a ; ^b ; Weilin Yan^a ; ^c ; Yanye Zhu^a ; Yiwen Xu^a ; Ming Guo^d ; Shulin Zhuang^a ; ^b ; ^{shulin@zju.edu.cn}
• 关键词：Triazole ; Androgen receptor ; Metabolism ; CYP450 ; Steroid hormone
• 刊名：Environmental Pollution
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：222
• 期：Complete
• 页码：504-512
• 全文大小：1626 K
• 卷排序：222

文摘

The anti-androgenic activity of five triazole fungicides was evaluated. No significant changes of anti-androgenic activity occur prior and after the metabolism. Tebuconazole, uniconazole, hexaconazole, penconazole, bitertanol potently inhibit CYP3A4. The anti-androgenic activity is highly correlated with the inhibition potency toward CYP3A4. Our study is helpful to the health risk assessment of triazole fungicides.