Benzotriazole UV 328 and UV-P showed distinct antiandrogenic activity upon human CYP3A4-mediated biotransformation

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• 作者：Shulin Zhuang^a ; ^b ; ^{shulin@zju.edu.cn} ; Xuan Lv^a ; ^c ; Liumeng Pan^a ; Liping Lu^a ; Zhiwei Ge^a ; Jiaying Wang^a ; Jingpeng Wang^a ; Jinsong Liu^d ; Weiping Liu^a ; Chunlong Zhang^e ; ^{zhang@uhcl.edu}
• 关键词：Benzotriazole UV stabilizers ; Androgen receptor ; Metabolism ; Molecular modeling ; Mass spectrometry
• 刊名：Environmental Pollution
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：220
• 期：part_PA
• 页码：616-624
• 全文大小：1918 K
• 卷排序：220

文摘

Two of the 8 BUVSs (UV-328 and UV-P) showed altered toxicity upon metabolism. UV-328 showed more potent antiandrogenic activity after CYP3A4-mediated metabolism. UV-328 can be metabolized into mono- and di-hydroxylated (OH) metabolites. Sites of metabolism of UV-328 occur mainly at the alicyclic hydrocarbon atom. Hydroxylation of BUVSs may present risk concern to human health.