A surface-grafted ligand functionalization strategy for coordinate binding of doxorubicin at surface of PEGylated mesoporous silica nanoparticles: Toward pH-responsive drug delivery

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• 作者：Qing Zhang ; ^{zhtsing101@sina.com} ; Haoyu Zhao ; Dong Li ; Liping Liu ; Shuhu Du ; ^{shuhudu@njmu.edu.cn}
• 关键词：Mesoporous silica nanoparticles ; pH-Response ; Coordinate bonds ; Targeting ; Doxorubicin
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：149
• 期：Complete
• 页码：138-145
• 全文大小：2135 K
• 卷排序：149

文摘

Iminodiacetic acid as a ligand was grafted on the vast surface of mesopores. Doxorubicin was loaded at surface of PEGylated mesoporous silica nanoparticles via coordinate binding. Enhanced drug loading, pH-responsive release and prolonged drug circulation time were achieved.