Functional polymorphisms in the interleukin-12 gene contribute to cancer risk: Evidence from a meta-analysis of 18 case-control studies

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• 作者：Liping Zhou ; Fan Yao ; Hong Luan ; Yinling Wang ; Xihua Dong ; Wenwen Zhou ; Qihui Wang
• 关键词：IL-12 ; interleukin-12 ; UTR ; untranslated region ; IVS ; intervening sequence ; VNTR ; variable number tandem repeat ; HuGE ; Human Genome Epidemiology ; HWE ; Hardy&ndash ; Weinberg equilibrium ; OR ; odds ratio ; CI ; confidence interval ; SNP ; single nucleotide polymo
• 刊名：Gene
• 出版年：2012
• 出版时间：15 November, 2012
• 年：2012
• 卷：510
• 期：1
• 页码：71-77
• 全文大小：829 K

文摘

Background

Emerging evidence from preclinical and clinical studies has shown that interleukin-12 (IL-12) has some effectiveness against endogenously arising carcinogenesis. Several potentially functional polymorphisms of IL-12 gene have been implicated in cancer risk, but individually published studies showed inconclusive results. The aim of this study was to investigate the association between IL-12 polymorphisms and cancer risk.

Methods

The MEDLINE, EMBASE, Web of science and CBM databases were searched for all articles published up to June 10, 2012 that addressed IL-12 polymorphisms and cancer risk. Statistical analyses were performed using RevMan 5.1.6 and STATA 12.0 softwares.

Results

Eighteen studies were included with a total of 6463 cancer cases and 7412 healthy controls. We found that the 3'UTR A > C (rs3212227) polymorphism of IL-12B gene was associated with significantly increased overall risk of cancers using random effects model (C vs A: odds ratio [OR] = 1.14, 95 % confidence interval [CI]: 1.02-1.27; AC + CC vs AA: OR = 1.20, 95 % CI: 1.01-1.43). However, the 3'UTR G > A (rs568408), IVS2 T > A (rs582054) and 5'UTR T > G (rs2243115) polymorphisms of IL-12A gene did not appear to have an influence on cancer susceptibility. Further subgroup analyses showed that the 3'UTR A > C (rs3212227) polymorphism was associated with increased cancer risks in the subgroups of Asians, cervical and nasopharyngeal cancers.

Conclusions

Results from the current meta-analysis indicates that the 3'UTR A > C (rs3212227) polymorphism of IL-12B gene might be a potential biomarker for cancer risk among Asians, especially for cervical and nasopharyngeal cancers.