Efficient delivery of paclitaxel into ASGPR over-expressed cancer cells using reversibly stabilized multifunctional pullulan nanoparticles

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• 作者：Liping Huang^a ; ¹ ; Yutong Wang^a ; ¹ ; Xiang Ling^a ; ^b ; Birendra Chaurasiya^a ; Chen Yang^a ; Yunai Du^a ; Jiasheng Tu^a ; ^{Jiashengtu@aliyun.com} ; Yerong Xiong^a ; ^c ; Chunmeng Sun^a ; ^{suncm_cpu@hotmail.com} ; ^{suncm1985@gmail.com}
• 关键词：Pull ; pullulan ; LA ; lipoic acid ; Pull-LA-CLNPs or CLNPs ; core-crosslinked pullulan nanoparticles ; Pull-LA-NCLNPs or NCLNPs ; non-crosslinked pullulan nanoparticles ; ASGPR ; asialoglycoprotein receptor ; PTX ; paclitaxel ; AHG ; anhydroglucosidic
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：159
• 期：Complete
• 页码：178-187
• 全文大小：2377 K
• 卷排序：159

文摘

Pullulan was first used to establish reduction-sensitive nano-micelles. The nano-micelles specifically target ASGPR overexpressed cell lines. The nano-micelles can reversibly core-crosslink under different conditions. The nano-micelles showed the longest circulation versus controls.