- 作者：J. Peuskens<sup>1sup> ; V. Porsdal<sup>2sup> ; J. Pecenak<sup>3sup> ; P. Handest<sup>4sup> ; Y. D’ ; yachkova<sup>5sup> ; R. Brousil<sup>6sup> ; M. Casillas<sup>7sup> ; W. Deberdt<sup>8sup>
- 刊名：European Psychiatry
- 出版年：2011
- 出版时间：2011
- 年：2011
- 卷：26
- 期：Complete
- 页码：1473
- 全文大小：13 K
ss=""h4"">Introduction, objectives and aims
To evaluate the outcome of patients with schizophrenia during maintenance treatment with OLAI.ss=""h4"">Methods
Data from three studies with OLAI were pooled and patients classified according to a cluster analysis [Lipkovich, Psychiatry Res, 2009] into five categories according severity of psychiatric symptoms (sx) and functional impairment (imp):
A (minimal sx/mild imp),
B (minimal sx/moderate imp),
C (moderate sx/mild to moderate imp),
D (moderate sx/severe imp),
E (moderate to severe sx/severe imp).
Improvement was defined as a change from B or C to A, or from D or E to A, B or C. Changes between the categories in the 6 months were analyzed. Stepwise logistic regression modeling was done to determine factors associated with improvement.
ss=""h4"">Results
1182 patients were classified. Patients who remained in the studies at 6 months had lower baseline CGI-S (3.04 vs 3.28, p < 0.001), lower PANSS (61.38 vs 64.05, p = 0.012) and higher QLS (1.76 vs 1.39, p = 0.001). (Table 1) As patients in category A couldn’t improve and in category D&E couldn’t worsen, 261(39 % ) patients from categories B, C, D and E improved and only 55(10 % ) from categories A, B and C got worse during 6 months. Baseline factors associated with improvement were: baseline category (p < 0.001), CGI-S score (p = 0.022), and PANSS positive (p = 0.003)
ss=""h4"">Conclusions
Majority of patients with schizophrenia who stay on 6 months treatment with OLAI improve or maintain their symptoms and functioning level. The strongest factor associated with a higher chance of improvement was poor baseline category.