Neutrophil gelatinase-associated lipocalin production negatively correlates with HK-2 cell impairment: Evaluation of NGAL as a marker of toxicity in HK-2 cells

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• 作者：Martina Hauschke^a ; Erika Rou&scaron ; arová ; ^a ; Pavel Flí ; dr^a ; ^b ; Jan Čapek^a ; Antoní ; n Libra^a ; ^b ; Tomá ; &scaron ; Rou&scaron ; ar^a ; ^{Tomas.Rousar@upce.cz}
• 关键词：NGAL ; HK-2 cells ; In vitro nephrotoxicity ; Cell viability ; Nephrotoxicity markers
• 刊名：Toxicology in Vitro
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：39
• 期：Complete
• 页码：52-57
• 全文大小：763 K
• 卷排序：39

文摘

Production of the NGAL lipocalin in HK-2 cells is described. The human kidney 2 (HK-2) cells can produce NGAL continuously. The NGAL production correlates negatively with cell viability. Gene expression of NGAL is not increased after HK-2 cells impairment. NGAL production could be used as a new specific marker of HK-2 cell damage.