UPEI-400, a conjugate of lipoic acid and scopoletin, mediates neuroprotection in a rat model of ischemia/reperfusion
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- 作者：Barry J. Connell<sup>asup> ; Monique C. Saleh<sup>asup> ; Desikan Rajagopal<sup>csup> ; Tarek M. Saleh<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>tsaleh@uoguelph.casup>
- 关键词：Stroke ; Antioxidant ; Co-drug ; Reperfusion-injury ; Animal model
- 刊名：Food and Chemical Toxicology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：100
- 期：Complete
- 页码：175-182
- 全文大小：1128 K
- 卷排序：100
文摘
Scopoletin decreased infarct volume following stroke at 1.0 mg/kg. UPEI-400 was ∼1000 times more potent than scopoletin following stroke. UPEI-400 was effective even when administered 150 min post-reperfusion.