High efficiency succinic acid production from glycerol via in situ fibrous bed bioreactor with an engineered Yarrowia lipolytica

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• 作者：Chong Li^a ; Xiaofeng Yang^b ; Shi Gao^a ; Huaimin Wang^a ; Carol Sze Ki Lin^a ; ^{carollin@cityu.edu.hk}
• 关键词：Yarrowia lipolytica ; Fibrous bed bioreactor ; Glycerol ; Succinic acid
• 刊名：Bioresource Technology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：225
• 期：Complete
• 页码：9-16
• 全文大小：1440 K
• 卷排序：225

文摘

Efficient SA production by Y. lipolytica via isFBB was developed at the first time. Three parameters of isFBB were optimized to achieved SA productivity of 1.46 g/L/h. Highest titer ever been reported (198.2 g/L) was obtained by fed batch strategy. Long term repeated fermentation demonstrated isFBB has great operation stability.