Dexamethazone protects against Escherichia coli induced sickness behavior in rats
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- 作者：A. Hanaa-Mansour ; Wedad A. Hassan ; wedad.abdallah@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Gehan S. Georgy
- 关键词：(LPS) ; lipopolysaccharide ; E. coli ; Escherichia coli ; (DEX) ; Dexamethazone ; (CRP) ; C-reactive protein ; (IFγ) ; Interferon gamma ; (NO) ; Nitric oxide ; (Casp-3) ; Caspase-3 ; (iNOS) ; inducible nitric oxide synthase.
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：1630
- 期：Complete
- 页码：198-207
- 全文大小：1436 K
文摘
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E. coli caused immunohistochemical changes and neurobehavioral dysfunction.
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Dexamethazone provides neuroprotection against E. coli-associated sickness behavior.
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The inhibition of inflammatory response was achieved through the reduction of IFNγ level.
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The expression of caspase-3 was suppressed, suggesting the inhibition of apoptosis by DEX.