Human β-defensin 3 suppresses Porphyromonas gingivalis lipopolysaccharide-induced inflammation in RAW 264.7 cells and aortas of ApoE-deficient mice
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- 作者：Tianying Biana ; b ; Lili Lia ; b ; Jinglu Lyua ; b ; Di Cuia ; b ; Lang Leib ; c ; Fuhua Yana ; b ; fhyan2005@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：hBD3 ; Anti-inflammatory ; MAPK pathway ; Atherosclerosis
- 刊名：Peptides
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：82
- 期：Complete
- 页码：92-100
- 全文大小：2423 K
文摘
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hBD3 inhibits the production of pro-inflammatory cytokines in vivo and in vitro.
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hBD3 attenuates plaque formation induced by P. gingivalis LPS in ApoE−/− mice.
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The anti-inflammatory effect might be related with inhibition of MAPK pathway.