Arterial stiffness in metabolic syndrome

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• 作者：Mona Adel^a ; ^{adel_mona@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ayman ELSheikh^a ; Sameh Sameer^a ; Waiel Haseeb^a ; Eman ELSheikh^a ; Lamia Kheder^a
• 关键词：AVP ; aortic velocity propagation ; FMD ; flow mediated dilatation ; WC ; waist circumference ; TC ; total cholesterol ; TG ; triglycerides ; HDL ; high density lipoprotein ; SBP ; systolic blood pressure ; DBP ; diastolic blood pressure ; FBS ; fasting blood sugar ; UA ; uric acid ; EPF ; epicardial fat ; IVS ; interventricular septum ; E/e&prime ; filling pressure ; AST ; aspartate transaminase ; ALT ; alanine transaminase ; CRP ; C reactive protein
• 刊名：Journal of the Saudi Heart Association
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：28
• 期：4
• 页码：249-256
• 全文大小：1344 K

文摘

Arterial stiffness is increasingly recognized as an important determinant of cardiovascular risk and may be directly involved in the process of atherosclerosis. As atherosclerosis leads to increased arterial resistance and decrease the flow propagation speed within the arterial lumen, a similar decrease in aortic flow propagation with increased downstream resistance is detected, so aortic flow propagation velocity AVP was evaluated in many studies as a new parameter of aortic stiffness.

Aim

To measure arterial stiffness using the new parameter AVP and compare it to flow mediated dilatation FMD as a parameter of endothelial dysfunction in patients with metabolic syndrome MS.

Methods

AVP (assessed by transthoracic echocardiography) and FMD (assessed by brachial artery reactivity test) were measured in 100 patients with MS (Group 1) and were compared to 14 normal subjects (Group 2).

Results

Patients with MS had significantly lower values of AVP as compared to the normal subjects; 36 ± 5 cm/s vs 57 ± 5, p < 0.05, and lower FMD; 6% ± 1 vs 17 ± 3 p < 0.05 as well, there was significant correlations between AVP and FMD (r = 0.89, p < 0.001).

Conclusion

Transthoracic echocardiographic determination of AVP is a simple practical method and correlates well with FMD in patients with MS.