Differential role of calpain-dependent protein cleavage in intermediate and long-term operant memory in Aplysia
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- 作者：Lisa C. Lyons ; lyons@bio.fsu.edu ; Jacob S. Gardner ; Cassidy T. Lentsch ; Catherine E. Gandour ; Harini C. Krishnan ; Eric J. Noakes
- 关键词：Associative memory ; Learning ; Aplysia ; Calpain ; Protein kinase M ; Protein cleavage
- 刊名：Neurobiology of Learning and Memory
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：137
- 期：Complete
- 页码：134-141
- 全文大小：531 K
- 卷排序：137
文摘
Inhibition of calpain activity with calpeptin or MDL-28170 prevented ITM formation. Calpain inhibition prior to training blocked the induction of LTM. Inhibiting calpain activity immediately after training impaired ITM but not LTM. Calpain activity at 6 h post-training is necessary for maintenance of 24 h LTM. Calpains function in multiple roles in associative memory formation.