Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase
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- 作者：Li Phing Liew1 ; Zun Yi Lim2 ; Matan Cohen3 ; Ziqing Kong4 ; Lisette Marjavaara4 ; Andrei Chabes4 ; 5 ; Stephen D. Bell2 ; 3 ; 6 ; stedbell@indiana.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA replication ; replication fork ; archaea ; hydroxyurea ; Sulfolobus ; DNA damage
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：17
- 期：6
- 页码：1657-1670
- 全文大小：3259 K
文摘
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Sulfolobus has a HU-insensitive class II ribonucleotide reductase
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HU impairs DNA replication and is toxic to Sulfolobus cells
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HU treatment leads to selective loss of the regulatory subunit of DNA primase