Up-regulation of CYLD enhances Listeria monocytogenes induced apoptosis in THP-1 cells

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• 作者：Changzhi Xu^a ; ¹ ; Ling Yang^a ; ¹ ; Yuan Yuan^b ; ¹ ; Fei Du^c ; Shumin Wang^a ; Xiangfang Wang^a ; Lin Zhu^a ; Buchang Zhang^a ; ^{zhbc@ahu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; David Weaver^a ; ^{david.weaver.t@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Listeria monocytogenes ; CYLD ; Apoptosis
• 刊名：Microbial Pathogenesis
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：90
• 期：Complete
• 页码：50-54
• 全文大小：764 K

文摘

m>Listeria monocytogenesm> (m>Lmm>), a facultative anaerobic gram-positive bacterium, causes listeriosis. Immune cell apoptosis is considered to be one pathogenic factor for listeriosis. As a deubiquitinase, CYLD is an important regulator both in innate immune response and apoptosis by negatively modulating NF-κB pathway. However the role of CYLD in m>Lmm> induced apoptosis remains unclear. Here we found that CYLD is significantly up-regulated in macrophages upon its infection. There is a moderate decrease in m>Lmm> proliferation and apoptotic cells m>inm> siRNA-induced CYLD knockdown THP-1 cells. Thereby CYLD may be involved in cell apoptosis mediated by m>Lmm> infection and its proliferation.