Placental telomere length decline with gestational age differs by sex and TERT, DNMT1, and DNMT3A DNA methylation
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- 作者：Samantha L. Wilsona ; b ; swils6@alumni.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Yao Liua ; b ; yao.liu@alumni.ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Wendy P. Robinsona ; b ; wrobinson@cfri.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Telomere length ; Telomerase ; DNA methylation ; DNA methyltransferase (DNMT) ; Preeclampsia ; Intrauterine growth restriction
- 刊名：Placenta
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：48
- 期：Complete
- 页码：26-33
- 全文大小：1436 K
文摘
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Male sex and gestational age negatively associate with placental telomere length.
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Placental telomere length was not altered in preeclampsia or IUGR.
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Telomere length was associated with altered DNAm within TERT, DNMT1, and DNMT3a.