Autophagy-related protein expression in the substantia nigra and eldepryl intervention in rat models of Parkinson׳s disease
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- 作者：Bin Liu ; liubintsh68@126.com" class="auth_mail" title="E-mail the corresponding author ; Jing Sun ; Jinxia Zhang ; Wenjing Mao ; Yuanyuan Ma ; Shiying Li ; Xiaohua Cheng ; Chaonan Lv
- 关键词：PD ; Parkinson׳s disease ; LC3 ; microtubule-associated protein 1 light chain 3 ; PBS ; phosphate buffered solution
- 刊名：Brain Research
- 出版年：2015
- 出版时间：2 November 2015
- 年：2015
- 卷：1625
- 期：Complete
- 页码：180-188
- 全文大小：9922 K
文摘
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Autophagic activity was activated in the substantia nigra of rat models of Parkinson׳s disease.
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Autophagy participates in the onset and development of Parkinson׳s disease.
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Eldepryl exerts therapeutic effect on Parkinson׳s disease possibly by inhibiting the nerve cell autophagy.
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This provides a novel pathway and target for drug treatment for Parkinson׳s disease.