Unraveling the roles of Atg4 proteases from autophagy modulation to targeted cancer therapy
详细信息 查看全文
- 作者：Lan Zhanga ; 1 ; Jingjing Lia ; 1 ; Liang Ouyanga ; 1 ; Bo Liua ; liubo2400@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yan Chengb ; chengyan0677@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Atg4 protease ; Autophagy ; Atg8/LC3 ; Apoptosis ; Targeted cancer therapy
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：373
- 期：1
- 页码：19-26
- 全文大小：1552 K
文摘
- •
We focus on the roles of the human Atg4 family in the LC3 conjugation system and their function in apoptosis.
- •
We discuss the roles of Atg4 proteases in several types of cancer.
- •
We demonstrate the development of Atg4 and its targeted candidate drugs in cancer.
- •
We further explore the roles of human Atg4 proteases as potential novel targets for cancer therapy.