Beclin-1: Autophagic regulator and therapeutic target in cancer

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• 作者：Lei-lei Fu^a ; Yan Cheng^b ; Bo Liu^a ; ^{liubo2400@163.com}
• 关键词：Beclin-1 ; Autophagy ; Interactome ; Cancer
• 刊名：The International Journal of Biochemistry and Cell Biology
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：45
• 期：5
• 页码：921-924
• 全文大小：536 K

文摘

Beclin-1 (the mammalian ortholog of yeast ATG6) has been well-characterized to play a pivotal role in autophagy that is a major catabolic pathway in which the cell degrades macromolecules and damaged organelles. Beclin-1 structure has been identified to contain three identifiable domains, including a short Bcl-2-homology-3 (BH3) motif, a central coiled-coil domain (CCD) and a C-terminal half encompassing the evolutionarily conserved domain (ECD). Recent data indicate that Beclin-1 may interact with some co-factors such as Class III phosphatidylinositol 3-kinase (PI3KCIII)/Vps34, Vps15, ATG14L/Barkor, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, Survivin, Akt and Bcl-2/Bcl-X_L to positively or negatively orchestrate the Beclin-1 interactome, thereby co-regulating the autophagy process. Here, we summarize that Beclin-1 serves not only as a key autophagic regulator with its specific interactors, but as a potential therapeutic target in cancer.