Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking

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• 作者：Sayak Bhattacharya ; Kevin E. McElhanon ; Liubov V. Gushchina ; Noah Weisleder ; ^{noah.weisleder@osumc.edu}
• 关键词：Phosphatidylinositol-4 ; 5-bisphosphate 3-kinase ; PI3K ; Protein kinase B ; AKT ; Endocytosis ; Exocytosis ; Membrane trafficking ; Caveolae ; Clathrin
• 刊名：Life Sciences
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：167
• 期：Complete
• 页码：39-45
• 全文大小：452 K
• 卷排序：167

文摘

Phosphatidylinositol-4,5-bisphosphate 3-kinases (PI3Ks) are regulatory enzymes involved in the generation of lipid species that modulate cellular signaling pathways through downstream effectors to influence a variety of cellular functions. Years of intensive study of PI3Ks have produced a significant body of literature in many areas, including that PI3K can mediate intracellular vesicular trafficking and through these actions contribute to a number of important physiological functions. This review focuses on the crucial roles that PI3K and AKT, a major downstream partner of PI3K, play in the regulation of vesicle trafficking during various forms of vesicular endocytosis and exocytosis.